Prorénine = rénine inactive ?

RIOK3 keeps MDA5 inactive.

RIG-I and MDA5 are cytoplasmic RNA sensors that recognize dsRNA patterns and activate MAVS to induce innate antiviral gene program. RNA sensing is regulated by ubiquitination in RIG-I while by phosphorylation in MDA5. Thus, de novo phosphorylation is an essential step for keeping MDA5 inactive. We identified a protein kinase RIO kinase 3 (RIOK3) targeting MDA5, and here discuss its possible rel...

California adolescents increasingly inactive.

Comment on osmotically inactive ions.

TO THE EDITOR: Nguyen et al. (6) attempted to show the physiological significance of the coefficients of their linear regression fit to the data (6) of Edelman et al. (Table 1) and a similar one of Boling et al. (Table 2) in regard to understanding the physiological factors responsible for dysnatremias. An understanding of this clinical condition is very important, but this paper has a number o...

RFC 3883 OSPF DC Inactive

OSPF is a link-state intra-domain routing protocol used in IP networks. OSPF behavior over demand circuits (DC) is optimized in RFC 1793 to minimize the amount of overhead traffic. A part of the OSPF demand circuit extensions is the Hello suppression mechanism. This technique allows a demand circuit to go down when no interesting traffic is going through the link. However, it also introduces a ...

Catalytically inactive telomerase in oncogenesis

Ends of human chromosomes called telomeres are essential for their structural and functional stability [1]. However, these DNA structures designed to function via a plethora of proteins and RNA molecules that bind them, encounter progressive shortening with each cell division due to the end replication problem. Terc, a long non coding (lnc)RNA and the reverse transcriptase TERT which uses Terc ...